secobarbital will lower the level or effect of estradiol vaginal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.secobarbital will lessen the extent or effect of levonorgestrel intrauterine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.Revision with the OED is actually a long-te